John Hardy (auth.), Ralph W. Richter MD, FACP, Brigitte's Alzheimer’s Disease: A Physician’s Guide to Practical PDF

By John Hardy (auth.), Ralph W. Richter MD, FACP, Brigitte Zoeller Richter DiplPharm (eds.)

ISBN-10: 0896038912

ISBN-13: 9780896038912

ISBN-10: 1475744854

ISBN-13: 9781475744859

ISBN-10: 1592596614

ISBN-13: 9781592596614

Alzheimer's disorder (AD) is not just affecting more and more huge numbers of aged or even middle-aged humans in a global epidemic, but additionally seems to be under-diagnosed and under-treated. In Alzheimer's illness: A Physician's consultant to useful administration, clinicians, scientists, and opinion leaders from around the globe supply a concise useful consultant to the overview, overview, and remedy of people with possible advert, illuminating the elemental biology underlying the disorder and outlining the numerous rising healing in addition to promising preventive instructions. at the scientific facet, the authors specialise in such concerns as early alterations and preclinical conditions-including gentle cognitive impairment and predementia AD-how the sufferer provides, the cutting-edge treatment, and the new neuropsychiatric features of advert. Late-life concerns are mentioned, in addition to the remedy of common comorbidities and the often-neglected dental care. at the functional aspect, information is obtainable to scientific prone and caregivers at the deep emotions of isolation, loneliness, and melancholy that the disease can create in caregivers, and on tips to conquer the resultant breakdown in communique with the sufferer. The authors additionally supply a understandable account of our present figuring out of advert, in addition to interesting destiny thoughts for its prevention and remedy, together with stem mobile treatment.
accomplished and sensible, Alzheimer's ailment: A Physician's consultant to useful administration not just deals physicians, caregivers, and all lay humans a readable future-oriented evaluate of the ailment, but additionally bridges the space among simple technological know-how and the typical demanding situations of treating and coping with advert patients.

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Extra resources for Alzheimer’s Disease: A Physician’s Guide to Practical Management

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 2000; 25: 402–405. 55. Lewis, J. : Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001; 293: 1487–1491. 56. Lilius, L. : Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer’s disease. Neurosci Lett 1999; 277: 29–32. 57. Baker, M. : Association of an extended haplotype in the tau gene with Progressive Supranuclear Palsy.

George Hyslop, P. : Genetic linkage studies suggest that Alzheimer s disease is not a single homogenous disorder. Nature 1990; 347: 194–197. 10. G. : Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease. Proc Natl Acad Sci USA 1987; 84: 5991–5994. 11. Van Broeckhoven, C. : The beta-amyloid precursor protein gene is tightly linked to the locus causing hereditary cerebral hemorrhage with amyloidosis of Dutch Type. Science 1990; 248: 488–490. 12.

34. Citron, M. : Mutant presenilins of Alzheimer’s disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3: 67–72. 35. Duff, K. : Increased amyloid β42(43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383: 710–713. 36. De Strooper, B. : Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998; 391: 387–390. The Genetics of Alzheimer’s Disease 19 37. S. : Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gammasecretase activity.

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Alzheimer’s Disease: A Physician’s Guide to Practical Management by John Hardy (auth.), Ralph W. Richter MD, FACP, Brigitte Zoeller Richter DiplPharm (eds.)


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