T. Hugh Jones's Advances in the Management of Testosterone Deficiency PDF

By T. Hugh Jones

ISBN-10: 3805586221

ISBN-13: 9783805586221

Testosterone has an incredible impression on significant organ platforms and tissues, together with mind, metabolism, cardiovascular in addition to musculoskeletal and immune platforms. overlaying many medical parts, this ebook will pay specific consciousness to the prognosis and administration of hypogonadism, discussing present instructions, biochemical evaluation, new innovations in testosterone alternative remedy and long term tracking of handled males. moreover the function of testosterone deficiency in getting older, weight problems, muscle functionality and frailty and erectile disorder is covered.Recent proof for the function of testosterone within the pathogenesis of power ailments similar to diabetes, heart problems and osteoporosis is said. New advancements within the capability therapy of those scientific stipulations also are. offered. essentially of curiosity to endocrinologists, urologists, andrologists and sexologists, the diversity of themes coated can be appropriate to fundamental care physicians, gerontologists, diabetologists and cardiologists.

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Extra resources for Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37)

Example text

Effects on sexual behavior were comparable to those of parenteral administration of 200 mg TE every 20 days. 34 Gooren Transdermal Delivery Testosterone can be delivered to the circulation through intact skin, both genital and nongenital [1, 2]. Transdermal administration delivers testosterone at a controlled rate into the systemic circulation avoiding hepatic first pass and reproducing the diurnal rhythm of testosterone secretion, without the peak and through levels observed in long-acting testosterone injections.

Testosterone gel is hydroalcoholic, 1% (10 mg testosterone/g gel) and between 5 and 10 g gel/day is administered, amounting to 50 and 100 mg testosterone per application. The gel Advances in Testosterone Replacement Therapy 35 Day 0 Serum T (nmol/l) 40 Day 1 40 40 30 30 20 20 20 10 10 10 30 0 0 0 0 8 16 0 24 8 16 24 40 40 30 30 20 20 10 10 0 8 16 24 Time (h) Day 180 Day 90 Serum T (nmol/l) Day 30 T patch T gel 100 mg T gel 50 mg T gel 50 -Ͼ75 mg T gel 100 -Ͼ75 mg 0 0 0 8 16 Time (h) 24 0 8 16 Time (h) 24 Fig.

More evidence would be required as to the cut-off age for defining ‘elderly’. m. m. 35 30 Testosterone (nmol/l) Testosterone (nmol/l) 40 15 20 15 10 5 0 1 2 3 4 5 Day 6 7 8 0 1 2 3 4 5 Day 6 7 8 0 1 2 3 4 5 Day 6 7 8 0 1 23 21 19 17 15 12 11 10 9 8 13 11 9 7 5 2 3 4 Day 5 6 7 Fig. 1. Intra-individual variability in plasma testosterone in 8 normal men aged 25–60 years in samples taken between 09:00 and 10:00 h and between 16:00 and 17:00 h on at least 6 separate days over a 1-month period [reproduced from 14].

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Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37) by T. Hugh Jones


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