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By W. N. Aldridge (eds.)

ISBN-10: 1349010855

ISBN-13: 9781349010851

ISBN-10: 1349010871

ISBN-13: 9781349010875

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Extra info for A Symposium on Mechanisms of Toxicity

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Thus, Pace & McDermott (1952) showed that methionine sulphoximine is a potent inhibitor of glutamine synthetase. It is evident that L-methionine sulphoxiCHa I I O=S=NH CH2 I CH2 I I CHNH 3 + cooFIG. 6. Methionine sulphoximine. A. Meister, R. A. Ronzio, W. B. Rowe, J. D. Gass, & S. L. N. Rao mine {as well as the corresponding sulphone and sulphoxide) can exist in conformations that are analogous to that proposed earlier for enzyme bound L-glutamic acid. Thus, the a-carboxyl and a-amino groups of the methionine derivatives can attach to the corresponding enzyme binding sites for L-glutamic acid.

1. Lg/kg) at time 0, given during a brief hexobarbitone anaesthesia (17 mg/kg, intraperitoneally). Two groups of eight rats, one receiving atropine sulphate (50 mg/kg, intraperitoneally) a few minutes before the soman injection. The animals were kept together in groups of four in cages of 25 x 25 x 25 em. E. of mean. 33 Anticholinesterases in Hypothermia 36·5° and 37·5°C and the tail temperature approximately 1oc above the room temperature. Recently it was found (Meeter, 1969) that if such an animal is injected with a suitable dose of an anti-ChE, the tail temperature responds by rising to 30°C or higher, whereas other areas of the skin remain completely passive, that is to say their temperature only drops with the body temperature.

2. A tail response can be evoked in the rat by slowly raising the body temperature above the set point for heat release (SPHR). This was done with the aid of radiant heat from incandescent lamps. Recent experiments (Meeter, 1969) showed that following an injection of a suitable dose of an anti-ChE, the SPHR is drastically lowered, and then gradually regains its normal level during the subsequent hours. Fig. 4 illustrates an experiment in which a small amount of soman was injected intraventricularly with the aid of a guide-tube placed through the skull on the previous day.

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A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)

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